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Accumulation of somatostatin receptor-specific analogs [ 111 In]In-DOTA-TATE (In-DOTA-TATE) and [ 111 In]In-DOTA-NOC (In-DOTA-NOC) in different renal cellular experimental models (incubation time = 30 min).

Journal: Pharmaceuticals

Article Title: Validation of Freshly Isolated Rat Renal Cells as a Tool for Preclinical Assessment of Radiolabeled Receptor-Specific Peptide Uptake in the Kidney

doi: 10.3390/ph16050696

Figure Lengend Snippet: Accumulation of somatostatin receptor-specific analogs [ 111 In]In-DOTA-TATE (In-DOTA-TATE) and [ 111 In]In-DOTA-NOC (In-DOTA-NOC) in different renal cellular experimental models (incubation time = 30 min).

Article Snippet: [DOTA 0 , D-Phe 1 , 1-Nal 3 ]-octreotide (DOTA-NOC), [DOTA 0 , Tyr 3 , Thr 8 ]-octreotide (DOTA-TATE), minigastrins (MG) DTPA-MG0 (DTPA- D Glu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH 2 ), DOTA-MG11 (DOTA- D Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH 2 ), DOTA-MG11 (DOTA- D Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH 2 ), DOTA-MG45 (DOTA- D Gln 6 -Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH 2 ), and DOTA-MG47 (DOTA- D Gln 6 -Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH 2 ) were purchased from piCHEM (Graz, Austria).

Techniques: Incubation

Comparative analysis of the active and passive cellular accumulation of selected radiolabeled compounds ( n = 4) using rat-isolated renal cells. Accumulation at 37 °C is considered 100%. (Lu-DOTA-TATE = [ 177 Lu]Lu-DOTA-TATE; Lu-DOTA-NOC = [ 177 Lu]Lu-DOTA-NOC; Tc-albumin = [ 99m Tc]Tc-albumin; Tc-DMSA = [ 99m Tc]Tc-DMSA; Tc-MAG3 = [ 99m Tc]Tc-MAG3).

Journal: Pharmaceuticals

Article Title: Validation of Freshly Isolated Rat Renal Cells as a Tool for Preclinical Assessment of Radiolabeled Receptor-Specific Peptide Uptake in the Kidney

doi: 10.3390/ph16050696

Figure Lengend Snippet: Comparative analysis of the active and passive cellular accumulation of selected radiolabeled compounds ( n = 4) using rat-isolated renal cells. Accumulation at 37 °C is considered 100%. (Lu-DOTA-TATE = [ 177 Lu]Lu-DOTA-TATE; Lu-DOTA-NOC = [ 177 Lu]Lu-DOTA-NOC; Tc-albumin = [ 99m Tc]Tc-albumin; Tc-DMSA = [ 99m Tc]Tc-DMSA; Tc-MAG3 = [ 99m Tc]Tc-MAG3).

Article Snippet: [DOTA 0 , D-Phe 1 , 1-Nal 3 ]-octreotide (DOTA-NOC), [DOTA 0 , Tyr 3 , Thr 8 ]-octreotide (DOTA-TATE), minigastrins (MG) DTPA-MG0 (DTPA- D Glu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH 2 ), DOTA-MG11 (DOTA- D Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH 2 ), DOTA-MG11 (DOTA- D Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH 2 ), DOTA-MG45 (DOTA- D Gln 6 -Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH 2 ), and DOTA-MG47 (DOTA- D Gln 6 -Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH 2 ) were purchased from piCHEM (Graz, Austria).

Techniques: Isolation